Angiotensin II receptor blocker combined with eplerenone or hydrochlorothiazide for hypertensive patients with diabetes mellitus

作者：Karashima Shigehiro^*; Yoneda Takashi; Kometani Mitsuhiro; Ohe Masashi; Mori Shunsuke; Sawamura Toshitaka; Furukawa Kenji; Yamagishi Masakazu; Takeda Yoshiyu

来源：Clinical and Experimental Hypertension, 2016, 38(7): 565-570.

DOI：10.3109/10641963.2016.1151526

• Aldosterone
• adiponectin
• combination therapy
• diabetes
• eplerenone

Experimental models recently suggested an interaction between aldosterone and adipose tissue, but clinical investigation has been limited. We studied the effects of eplerenone compared to hydrochlorothiazide (HCTZ) on blood pressure (BP), glucose, and lipid levels in 50 patients with essential hypertension (EHT) and type 2 diabetes mellitus whose BP failed to reach target levels with 8 mg of candesartan alone. BP improved similarly in both groups over the 12-month study period, but BMI, waist circumference, and LDL-cholesterol were decreased in the eplerenone group, while glycohemoglobin was elevated in the HCTZ group.

• 出版日期2016