Alzheimer's Disease Patients Generate Late and Reduced Cortical Activity For Movement Preparation

作者：Yener Goersev^*; Yilmaz Muesluem; Oguz Meral; Kurt Pinar

来源：Journal of Neurological Sciences-Turkish, 2010, 27(2): 150-159.

• Alzheimer's Disease
• movement related cortical potentials
• Bereitshaftspotential
• executive functions

Background: Alzheimer's disease (AD) is a common neurodegenerative disease that affects cognitive functions in the absence of motor signs. However, motor associated functional cortical changes mirror the changes of cognitive network in AD patients. The movement related cortical potentials (MRCP) can be used to investigate the cognitive processes prior to voluntary movement. The neuropsychological deficits that implicate disruption of involving frontal motor network in early AD would also cause alterations in all phases of MRCP. The present study aimed to investigate whether such changes occur in MRCPs of AD patients.
Methods: MRCP of twenty-three mild probable AD and twenty healthy, education-, gender-and age-matched control subjects were studied.
Results: AD patients differed from healthy control subjects on mini mental state examination (MMSE), both verbal and visual memory, verbal fluency, executive function and visuo-spatial test scores. AD patients showed significant changes in both early and late phases of Bereitshaftspotential (BP) than controls. Diminished amplitude and less preparation time for movement in MRCP recordings along with executive dysfunction were found.
Conclusion: These findings seem to reflect the disruption of frontal motor network during movement preparation in AD and may correspond to a loss of motor preplanning caused by deranged neuronal input into supplementary motor area (SMA).

• 出版日期2010