摘要
Human natural blood vessels have a three-layer structure including the tunica intima, tunica media, and tunica adventitia. These subtle structures endow healthy blood vessels with outstanding strength, elasticity, and compliance as well as excellent haemodynamic and anti-thrombus performance. Fabrication of a next generation vascular graft that mimics the structures and functions of natural blood vessels is becoming the pursuit of biomaterials and medical scientists. Here we fabricate a bio-inspired nanofiber three-layer vascular graft by electrospinning. The inner PLA/PCL layer is favorable for adhesion of human umbilical vein endothelial cells that could accelerate endothelialization. The middle PU/PCL layer provides superior mechanical properties (63.40 MPa, 266.78% in the longitudinal direction and 52.34 MPa, 319.72% in the lateral direction). The outer PLA/PCL layer with circumferentially aligned fibers is beneficial for guiding vascular smooth muscle cells in the circumferentially oriented direction. The bio-inspired three-layer vascular graft with strong mechanical properties and good cell biocompatibility will play an important role in vessel remodeling and regeneration.
- 出版日期2017-5-28
- 单位超分子结构与材料国家重点实验室; 中国科学院大学; 吉林大学; 第四军医大学; 北京航空航天大学; 中国科学院理化技术研究所; 中国人民解放军空军军医大学