科研之友
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摘要
Immunosenescence and inflammaging have been depicted for long as age-related heterogeneous blood phenotypic changes (%26quot;immunoaging%26quot;). Some of them can be reproduced in animal models either by accelerating telomere shortening or by forcing DNA damage response. According to these models, %26quot;immunoaging%26quot; is the consequence of replicative senescence of hematopoietic stem cells. %26lt;br%26gt;This increasing knowledge may impact oncogeriatrics in the future since (1) an increasing evidence links hematopoietic and cancer stem cells regulations; (2) immunosenescence may be linked to cancer immunotolerance and the increasing rate of cancer incidence with age; (3) immunoaging has a major consequence during cancer treatment, since it explains increased hematological toxicities observed in the elderly and (4) it favors secondary cancers and mainly hemopathies. %26lt;br%26gt;For all these reasons, aging biomarkers, among which are telomere length peripheral blood sampling but also analyses of telomere-linked proteins like shelterin complex or DNA-damage markers will probably be clinically relevant in the future.
- 出版日期2013-3
