科研之友
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摘要
We describe the nickel-catalyzed hydrocarboxylation of ynamides with CO2 and H2O to afford a variety of alpha-amino-alpha, beta-unsaturated esters with high regioselectivities. The selective alpha-carboxylation of ynamides with this catalytic protocol is unexpected in view of the electronic bias of ynamides and is in sharp contrast to our previous study in which a stoichiometric amount of Ni(0) was used to form a beta-carboxylated product exclusively. We revealed that this unexpected C-C bond formation was induced by the combination of Zn and MgBr2.
- 出版日期2017-7-14
