An experimental study of betadine irrigation for preventing infection during the natural orifice transluminal endoscopic surgery (NOTES) procedure

作者：Zheng Yong Zhi; Wang Dong; Gu Jun Jun; Zhou Miao Miao; Kong Xiang Yu; Deng Shang Xin; Su Xiao Ju; Yin Jie; Gong Yan Fang; Wu Ren Pei; Li Zhao Shen^*

来源：Journal of Digestive Diseases, 2011, 12(3): 217-222.

DOI：10.1111/j.1751-2980.2011.00499.x

• betadine
• animal study
• natural orifice transluminal endoscopic surgery (NOTES)
• porcine
• transcolonic approach
• transgastric approach

OBJECTIVE:
To study the effect and feasibility of using betadine irrigation of the gastrointestinal tract for preventing infection during the natural orifice transluminal endoscopic surgery (NOTES) procedure.
METHODS:
Twelve sows were used in this study. Four sows in the control group were lavaged with 500 mL saline. The eight sows in the experimental group were first lavaged with 500 mL saline and then irrigated with 200 mL betadine. A total of 5 mL of gastrointestinal (GI) tract fluid was collected before and after lavage, respectively, and 5 mL of peritoneal fluid was collected at the end of the NOTES procedure. A follow-up endoscopic examination of the GI tract was performed 24 h after NOTES. The animals were killed and necropsied after 3 weeks.
RESULTS:
Irrigation with betadine of the GI tract significantly reduced the bacterial load of GI fluid. One sow died of diaphragmatic injury. No inflammation, ulcer or bleeding were observed in the experimental group by endoscopy after 24 h. More adhesions and abscesses were found in the control group than in the experimental group after 3 weeks. Only one case of adhesion was observed in the experimental group using the transcolonic approach.
CONCLUSIONS:
Betadine irrigation of the GI tract is effective and feasible for preventing infection during the NOTES procedure. Further studies are needed for assessing the effectiveness and safety of betadine irrigation in the clinical application of NOTES.

• 出版日期2011-6
• 单位中国人民解放军第二军医大学