Assessing Ge-132 as an antioxidant in organic and water-containing media

作者：Vishtorskaya Antonina A; Saverina Evgeniya A; Pechennikov Valery M; Krylova Irina V; Lalov Andrey V; Syroeshkin Mikhail A^*; Egorov Mikhail P; Jouikov Viatcheslav V

来源：Journal of Organometallic Chemistry, 2018, 858: 8-13.

DOI：10.1016/j.jorganchem.2018.01.004

• Antioxidants
• Germanium sesquioxides
• Ge-132
• Cyclic voltammetry
• DPPH
• UV spectroscopy
• EPR
• HRMS

The antioxidant activity of Ge-132 (2-carboxyethylgermanium sesquioxide, [(O-0.5)(3)GeCH2CH2COOH](n)), a widely used organic germanium dietary supplement, was assessed by cyclic voltammetry and through its interaction with a stable radical 2,2,-diphenyl-1-picrylhydrazyl (DPPH) monitored by UV-Vis and EPR spectroscopy in water, CH3CN, DMF, MeOH, and their mixtures with water. The results obtained by these methods are coherent in that Ge-132 can manifest its antioxidant activity only in the absence of water because the latter hydrolyses its Ge-O-Ge fragment responsible for quenching free radicals. Thus, contrary to a common use of Ge-132 as a water-soluble agent, it can act as an antioxidant solely in a lipid environment, which is important for understanding the mechanism of its biological activity.

• 出版日期2018-3-1