Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons

作者：Chang Karen T^*; Niescier Robert F; Min Kyung Tai

来源：Proceedings of the National Academy of Sciences, 2011, 108(37): 15456-15461.

DOI：10.1073/pnas.1106862108

The proper distribution of mitochondria is particularly vital for neurons because of their polarized structure and high energy demand. Mitochondria in axons constantly move in response to physiological needs, but signals that regulate mitochondrial movement are not well understood. Aside from producing ATP, Ca2+ buffering is another main function of mitochondria. Activities of many enzymes in mitochondria are also Ca2+-dependent, suggesting that intramitochondrial Ca2+ concentration is important for mitochondrial functions. Here, we report that mitochondrial motility in axons is actively regulated by mitochondrial matrix Ca2+. Ca2+ entry through the mitochondrial Ca2+ uniporter modulates mitochondrial transport, and mitochondrial Ca2+ content correlates inversely with the speed of mitochondrial movement. Furthermore, the miro1 protein plays a role in Ca2+ uptake into the mitochondria, which subsequently affects mitochondrial movement.

• 出版日期2011-9-13