Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata

作者：Weon Jin Bae; Yun Bo Ra; Lee Jiwoo; Eom Min Rye; Ko Hyun Jeong; Lee Hyeon Yong; Park Dong Sik; Chung Hee Chul; Chung Jae Youn; Ma Choong Je^*

来源：Biomolecules & Therapeutics, 2014, 22(3): 246-253.

DOI：10.4062/biomolther.2014.019

• Codonopsis lanceolate
• Steam and fermentation
• Neuroprotective activity
• Antioxidative activity
• Bax
• Caspase-3

Codonopsis lanceolate has been used as an herbal medicine for several lung inflammatory diseases, such as asthma, tonsillitis, and pharyngitis. Previously, we showed the neuroprotective effect of steamed and fermented C. lanceolate (SFC) in vitro and in vivo. In the current study, the treatment of HT22 cells with SFC decreased glutamate-induced cell death, suggesting that SFC protected HT22 cells from glutamate-induced cytotoxicity. Based on these, we sought to elucidate the mechanisms of the neuroprotective effect of SFC by measuring the oxidative stress parameters and the expression of Bax and caspase-3 in HT22 cells. SEC reduced contents of ROS, Ca2+ and NO. Moreover, SFC restored contents of glutathione and glutathione reductase as well as inhibited Bax and caspase-3 activity in HT22 cells. These results indicate that steamed and fermented C. lanceolate (SFC) extract protected HT22 cells by anti-oxidative effect and inhibition of the expression of Bax and caspase-3.

• 出版日期2014-5-31