摘要
Objectives. Proton pump inhibitors (PPIs) are associated with an increased risk of bone fractures. This study sought to evaluate the effect of PPIs on biochemical markers of calcium and bone metabolism. %26lt;br%26gt;Methods. Prospective matched controlled study involving healthy adult males (age 18-50 years) suffering from frequent heartburn. Patients received standard-dose PPI for 12 weeks and were matched by age with healthy controls. Blood studies were taken at 0, 1 and 3 months for biochemical markers of mineral and bone metabolism. Two-way (time and PPI treatment) repeated measures analysis of variance (RM-ANOVA) and multiple linear regression were used for analysis. %26lt;br%26gt;Results. A total of 58 participants (29 per group) completed the study. Mean age of participants was 33.2 +/- 7.5 years. Baseline characteristics and biomarkers were similar for both groups except for higher BMI (28.6 vs. 25.6 kg/m(2), p=0.008) and serum C-terminal cross linked telopeptides of type I collagen [CrossLaps, (300 vs. 228 pg/ml, p=0.028)] in the PPI group. There was no difference in parathormone (PTH), ionized calcium, vitamin D, osteocalcin and CrossLaps between the PPI and control subjects (all non-significant; 2-way RM-ANOVA). Multiple linear regression modeling showed no effect of PPIs on any of the studied calcium or bone metabolism biomarkers. %26lt;br%26gt;Conclusion. PPI intake for 12 weeks has no measurable effect on calcium or bone metabolism in healthy young males.
- 出版日期2013-4