ASYMMETRIC SYNTHESIS OF (+)-MACHILIN F BY UNUSUAL STEREOSELECTIVE MITSUNOBU REACTION

作者：Harada Kenichi^*; Kubo Naoko; Tanabe Kazuma; Kubo Miwa; Esumi Tomoyuki; Hioki Hideaki; Fukuyama Yoshiyasu

来源：Heterocycles, 2011, 82(2): 1127-+.

DOI：10.3987/COM-10-S(E)88

• Talaumidin
• Machilin F
• Asymmetric Synthesis
• Mitsunobu Reaction
• Neurotrophic Activity

First synthesis of (+)-machilin F (1c) has been achieved in 16 steps as part of systematic synthetic studies on (-)-talaumidin (1) and its stereoisomers. The 2,3,4,5-tetrasubstituted tetrahydrofuran with the (2S,3S,4R,5R)-configuration has been constructed stereoselectively from diol 14 by Mitsunobu reaction.

• 出版日期2011-3-1