Association between the maternal serum levels of 19 eicosanoids and pre-eclampsia

作者：Long, Anxiong; Ma, Shungao; Li, Qian; Lin, Na; Zhan, Xia; Lu, Shuaijun; Zhu, Yuli; Jiang, Liansheng; Tan, Longyi^*

来源：International Journal of Gynecology & Obstetrics, 2016, 133(3): 291-296.

DOI：10.1016/j.ijgo.2015.10.024

• Eicosanoids
• Epoxyeicosatrienoic acid
• Hydroxyeicosatetraenoic acid
• Leukotriene B4
• Pre-eclampsia

Objective: To investigate whether serum levels of 19 eicosanoids are associated with pre-eclampsia. Methods: A case-control study was performed using data for pregnant women with pre-eclampsia, normotensive pregnant women, and nonpregnant women, for all of whom serum samples had been collected at a hospital in Shanghai, China, between December 2012 and December 2013. Ultra-performance liquid chromatography-tandem mass spectrometry was used to measure the serum levels of 19 eicosanoids. Results: Overall, 49 pregnant women with pre-eclampsia, 26 normotensive pregnant women, and 14 nonpregnant women were included. Women with pre-eclampsia had significantly higher serum levels of 11,12-epoxyeicosatrienoic acid (11,12-EET), the hydroxyeicosatetraenoic acids 5-HETE, 8-HETE, 12-HETE, and 15-HETE, and leukotriene B4 than did women with a normal pregnancy and nonpregnant women, both before and after the onset of pre-eclampsia (P < 0.01 for all comparisons). Women with severe pre-eclampsia had significantly higher serum levels of 5-HETE, 15-HETE, and leukotriene B4 than did women with mild pre-eclampsia, women with a normal pregnancy, and nonpregnant women (P < 0.01 for all comparisons). Conclusion: The eicosanoids 11,12-EET, 5-HETE, 8-HETE, 12-HETE, 15-HETE, and leukotriene B4 might play important parts in the occurrence and development of pre-eclampsia.

• 出版日期2016-6
• 单位宁波大学