A one-pot three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using atomized sodium in THF under sonic condition

作者：Pasha Mohamed Afzal^*; Shrivatsa Nagashree

来源：Ultrasonics Sonochemistry, 2014, 21(4): 1279-1283.

DOI：10.1016/j.ultsonch.2013.12.021

• Atomized sodium
• Aldehydes
• Methyl ketones
• Urea
• 4,6-Diarylpyrimidin-2(1H)-ones (DAPMs)
• Ultrasound

A simple and an efficient procedure for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones using atomized sodium/THF via a one-pot three-component Biginelli-like cyclocondensation of an aldehyde, a methyl ketone and urea under ultrasonic condition is developed. The method is mild and inexpensive; yields are high and the reactions go to completion within 10-15 min.

• 出版日期2014-7