Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus

作者：Martin Jerome C^*; Baeten Dominique L; Josien Regis

来源：Clinical Immunology, 2014, 154(1): 1-12.

DOI：10.1016/j.clim.2014.05.004

• IL-17
• Th17
• SLE

Despite the success of targeted therapies in managing immune-mediated inflammatory diseases (IMIDs) such as RA, IBDs, MS and psoriasis, unmet needs for such approach in SLE are widely recognized. In the past 2 years, exciting insights supporting previous lines of evidence on the role of the IL-23/IL-17 axis in SLE have emerged. This is of particular importance as IL-17 blockers have now moved successfully into the clinical space, as illustrated in psoriasis and ankylosing spondylitis. However, recent fundamental studies also highlighted unexPected aspects of IL-17/Th17 biology whose comprehension may prevent disappointing results of IL-17 targeting such as those obtained in Crohn%26apos;s disease. Therefore, establishing a current picture of the IL-17 pre-clinical situation in SLE is timely in order to plan future proof-of-concept studies in human.

• 出版日期2014-9