Posttraumatic Activity of Signal Pathways of Nuclear Factor kappa B in Mature Sensory Neurons

作者：Gushchina S V^*; Magoulas C B; Yousaf N; Richardson P M; Volkova O V

来源：Bulletin of Experimental Biology and Medicine, 2010, 149(4): 474-478.

• neuron
• transcription nuclear factor kappa B
• spinal ganglia

The aim of this study was to clear out whether injury to the peripheral nerve leads to activation of nuclear factor kappa B in mature spinal ganglia. Analysis of matrix RNA of nuclear factor kappa B-dependent genes (monocyte chemoattractant protein MCP-1 and inhibitor of nuclear factor kappa B I kappa B alpha) showed different levels of expression of these genes in the spinal ganglia in vivo after axotomy and in vitro after TNF-alpha stimulation. On the other hand, DNA-binding activity of nuclear factor kappa B increased in the spinal ganglia 6 h after axotomy and after 10-min incubation of sensory neuron culture with TNF-alpha. These data attest to possible involvement of nuclear factor kappa B in the posttraumatic regulation of gene transcription in spinal ganglion cells.

• 出版日期2010-10