MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria

作者:Sanchez Mateo I; Martinez Costas Jose*; Mascarenas Jose L; Eugenio Vazquez M
来源:ACS Chemical Biology, 2014, 9(12): 2742-2747.
DOI:10.1021/cb500552f

摘要

We report the discovery of a fluorogenic dye, N-1,N-3-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high resistance to photobleaching. Additionally, we show that a biotin-labeled MitoBlue derivative can be used as a handle for the delivery of streptavidin-tagged species to the mitochondria.

  • 出版日期2014-12