Hyptenolide, a new alpha-pyrone with spasmolytic activity from Hyptis macrostachys

作者：de O Costa Vicente Carlos; Tavares Josean F; Silva Andreza B; Duarte Marcelo C; Agra Maria de F; Barbosa Filho Jose M; de Souza Iara L L; da Silva Bagnolia A; Silva Marcelo S^*

来源：Phytochemistry Letters, 2014, 8: 32-37.

DOI：10.1016/j.phytol.2014.01.009

• Hyptis macrostachys
• Hyptenolide
• Spasmolytic activity

A new alpha-pyrone was isolated from aerial parts of Hyptis macrostachys Benth. Its structure was determined as 6R-[( 5'S, 6'S-diacetoxy)-1'Z,3'E-heptenyl]-5,6-dihydro-2H-pyran-2-one, named hyptenolide based on a combination of 1D and 2D NMR techniques and CD data. Hyptenolide inhibited the contractions induced by CCh ( IC50 = 1.7 +/- 0.3 x 10 (4) M) or histamine ( IC50 = 0.9 +/- 0.05 x 10 (4) M) in guinea pig ileum, demonstrating for the first time a pharmacological activity for the pyrone.

• 出版日期2014-5