Autosomal dominant inheritance of central centrifugal cicatricial alopecia in black South Africans

作者：Dlova Ncoza C^*; Jordaan Francois H; Sarig Ofer; Sprecher Eli

来源：Journal of the American Academy of Dermatology, 2014, 70(4): 679-U261.

DOI：10.1016/j.jaad.2013.11.035

• African
• black
• familial
• follicular degeneration syndrome
• genetic
• hair loss
• lymphocytic primary scarring alopecia
• scarring alopecia
• South Africa

Background: Central centrifugal cicatricial alopecia (CCCA) is the commonest type of primary scarring alopecia in women of African descent. Little is currently known about the disease genetics. %26lt;br%26gt;Objective: We sought to investigate patterns of inheritance in CCCA and ascertain the contribution of nongenetic factors such as hair-grooming habits to the pathogenesis of the disease. %26lt;br%26gt;Methods: Affected individuals with at least 1 available family member were recruited from 2005 through 2012 inclusive for pedigree analysis. CCCA was diagnosed on clinical and histopathological grounds. %26lt;br%26gt;Results: Fourteen index African families with 31 immediate family members participated in the initial screening. The female to male ratio was 29:2 with an average age of 50.4 years. All patients displayed histologic features typical for CCCA. Pedigree analysis suggested an autosomal dominant mode of inheritance. Hair-grooming habits were found to markedly influence disease expression. %26lt;br%26gt;Limitations: Small number of patients is a limitation. %26lt;br%26gt;Conclusion: CCCA can be inherited in an autosomal dominant fashion, with partial penetrance and a strong modifying effect of hairstyling and gender.

• 出版日期2014-4