Chronic Histiocytic Intervillositis with Cytomegalovirus Placentitis in a Case of Hydrops Fetalis

作者：Taweevisit Mana^*; Sukpan Kornkanok; Siriaunkgul Sumalee; Thorner Paul Scott

来源：Fetal and Pediatric Pathology, 2012, 31(6): 394-400.

DOI：10.3109/15513815.2012.659405

• chronic histiocytic intervillositis (CHI)
• cytomegalovirus
• placentitis
• delayed hypersensitivity

Chronic histiocytic intervillositis (CHI) is an infrequent inflammatory placental disorder associated with unfavorable pregnancy outcomes and a high rate of recurrence. This disorder is thought to reflect a maternal delayed hypersensitivity response to fetal antigen(s) in placental tissue. We report a case of a 20-week-gestation hydropic fetus in which the placenta showed chronic histiocytic intervillositis with cytomegalovirus placentitis. Immunophenotyping studies supported a delayed hypersensitivity response. This is the first report of these two diseases co-occurring, raising the possibility of a relationship between chronic histiocytic intervillositis and infection. Chronic histiocytic intervillositis may represent an idiosyncratic immune response, in this case to cytomegalovirus.

• 出版日期2012