Protein O-GlcNAcylation regulates Drosophila growth through the insulin signaling pathway

作者：Park Sujin; Park Si Hyoung; Baek Ju Yuel; Jy Ye Jin; Kim Kwan Soo; Roth Juergen; Cho Jin Won^*; Choe Kwang Min

来源：Cellular and Molecular Life Sciences, 2011, 68(20): 3377-3384.

DOI：10.1007/s00018-011-0640-7

• OGT
• O-GlcNAcase
• Size control
• Insulin
• Drosophila

Modification of nuclear and cytosolic proteins by O-linked N-acetylglucosamine (O-GlcNAcylation) is ubiquitous in cells. The in vivo function of the protein O-GlcNAcylation, however, is not well understood. Here, we manipulated the cellular O-GlcNAcylation level in Drosophila and found that it promotes developmental growth by enhancing insulin signaling. This increase in growth is due mainly to cell growth and not to cell proliferation. Our data suggest that the increase in the insulin signaling activity is mediated, at least in part, through O-GlcNAcylation of Akt. These results indicate that O-GlcNAcylation is one of the crucial mechanisms involved in control of insulin signaling during Drosophila development.

• 出版日期2011-10