Antidiabetic and antiacetylcholinesterase effects of ethyl acetate fraction of Chaenomeles sinensis (Thouin) Koehne fruits in streptozotocin-induced diabetic rats

作者：Sancheti Sandesh; Sancheti Shruti; Seo Sung Yum^*

来源：Experimental and Toxicologic Pathology, 2013, 65(1-2): 55-60.

DOI：10.1016/j.etp.2011.05.010

• Antioxidant
• Antiacetylcholinesterase
• Antidiabetic
• Chaenomeles sinensis
• Diabetic rats

The present study was intended to examine the effects of the supplementation of active alpha-glucosidase, alpha-amylase and lipase inhibitory ethyl acetate (CSE) fraction from the fruits of Chaenomeles sinensis (Thouin) Koehne on blood glucose (BG), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), aspartate aminotransaminase (AST), acetylcholinesterase (AChE) and antioxidant levels. The diabetic rats were treated orally with CSE at the doses of 50 and 100 mg/kg bw for 14 days. BG, TC, TG, HDL-C, ALT, AST and AChE levels were significantly reduced; on the other hand antioxidant levels were significantly increased in the treated groups. These observations suggest protective effects of CSE against STZ-induced diabetic dementia model.

• 出版日期2013-1