科研之友
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摘要
In this issue of Blood, Zhu et al identify a novel rare genotype mismatch in the testis-expressed gene TEX38 that is prognostic of blood and marrow transplant (BMT) mortality (see figure). 1 The single-nucleotide polymorphism (SNP) that was identified (rs200092801) in this first of its kind exome-wide association study (EXWAS) is a nonsynonymous variant, suggesting a functional consequence underlying this association. The hunt for prognostic and predictive biomarkers is a key component to precision medicine efforts, and the assessment by Zhu et al is an important step in that direction for those who receive BMT.
- 出版日期2018-5-31
