Discovery of new protein kinase CK2 inhibitors with 1,3-dioxo-2,3-dihydro-1H-indene core

作者：Liu, Zong-liang^*; Zhang, Ren-mei; Meng, Qing-guo; Zhang, Xiao-chen; Sun, Yuan

来源：Medchemcomm, 2016, 7(7): 1352-1355.

DOI：10.1039/c6md00189k

• ANION-PI INTERACTIONS
• POTENT
• CANCER
• TARGET

Protein kinase CK2 (CK2) is a ubiquitous serine/threonine protein kinase which serves as an attractive anticancer target. Herein we report new CK2 inhibitors with a 1,3-dioxo-2,3-dihydro-1H-indene core. Some derivatives showed much improved inhibitory activity on CK2, with an IC50 of 0.85 +/- 0.09 mu M for the best compound, SL-15. Our data provide a new scaffold for designing CK2 inhibitors and deserve further modifications.

• 出版日期2016
• 单位烟台大学