ALL-BFM 95 Treatment in Turkish Children with Acute Lymphoblastic Leukemia-Experience of a Single Center

作者：Kocak Ulker^*; Gursel Turkiz; Kaya Zuhre; Aral Yusuf Ziya; Albayrak Meryem; Keskin Ebru Yilmaz; Belen Burcu; Isik Melek; Oner Nergiz

来源：Pediatric Hematology and Oncology, 2012, 29(2): 130-140.

DOI：10.3109/08880018.2011.629859

• acute lymphoblastic leukemia
• ALL-BFM 95 protocol
• children

Little is known about the likelihood of curing children with high-dose chemotherapy regimens for treatment of childhood acute lymphoblastic leukemia (ALL) in Turkey. The authors here report their 13 years%26apos; experience with original ALL-BFM (Berlin-Franfurt-Munster) 95 protocol in a cohort of 140 Turkish children with ALL. Complete remission rate was 97.7% with a relapse rate of 12.9% and death rate 17.9% during a median follow-up of 69 months. The event-free survival (EFS), disease-free survival (DFS), and overall survival (OS) in these patients at 12 yearswere 75.0%, 87.1%, and 80.6%, respectively. These results show that ALL-BFM95 protocol is equally applicable in the experienced centers, even in developing countries without substantial treatment-related toxicity. High rate of infection deaths are to be reduced with correct policies.

• 出版日期2012-3