Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people

作者：Lai Shih Wei; Lin Cheng Li; Liao Kuan Fu^*

来源：International Psychogeriatrics, 2017, 29(9): 1535-1541.

DOI：10.1017/S1041610217000801

• Alzheimer's disease
• glaucoma
• older people
• Taiwan national health insurance program

Background: The purpose of this paper was to examine whether glaucoma could be a non-memory manifestation of Alzheimer's disease in older people.
Methods: We conducted a population-based, retrospective, case-control study to analyze the database of the Taiwan National Health Insurance Program. There were 1,351 subjects >= 65 years old with newly diagnosed Alzheimer's disease as the cases, and 5,329 subjects without any type of dementias as the controls during 2000-2011. The odds ratio (OR) and 95% confidence interval (CI) for the risk of Alzheimer's disease associated with glaucoma was estimated by the multivariable unconditional logistic regression model.
Results: After controlling for confounders, the multivariable logistic regression model demonstrated that the adjusted OR of Alzheimer's disease was 1.50 in subjects with glaucoma (95% CI 1.19, 1.89), compared to subjects without glaucoma.
Conclusions: Older people with glaucoma are associated with 1.5-fold increased odds of Alzheimer's disease in Taiwan. Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people. Further research is needed to confirm this issue.

• 出版日期2017-9
• 单位中国医科大学