Nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan

作者：Hamasuna Ryoichi^*; Yasuda Mitsuru; Ishikawa Kiyohito; Uehara Shinya; Takahashi Satoshi; Hayami Hiroshi; Yamamoto Shingo; Matsumoto Tetsuro; Minamitani Shinichi; Watanabe Akira; Iwamoto Aikichi; Totsuka Kyoichi; Kadota Junichi; Sunakawa Keisuke; Sato Junko; Hanaki Hideaki; Tsukamoto Taiji; Kiyota Hiroshi; Egawa Shin; Tanaka Kazushi; Arakawa Soichi; Fujisawa Masato; Kumon Hiromi; Kobayashi Kanao; Matsubara Akio; Naito Seiji; Tatsugami Katsunori; Ito Shin

来源：Journal of Infection and Chemotherapy, 2013, 19(4): 571-578.

DOI：10.1007/s10156-013-0637-2

• Neisseria gonorrhoeae
• Nationwide surveillance
• Antimicrobial susceptibilities
• Japan

Neisseria gonorrhoeae is one of the most important pathogens causing sexually transmitted infection, and strains that are resistant to several antimicrobials are increasing. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the first nationwide surveillance. The urethral discharge was collected from male patients with urethritis at 51 medical facilities from April 2009 to October 2010. Of the 156 specimens, 83 N. gonorrhoeae strains were tested for susceptibility to 18 antimicrobial agents. The prevalence of beta-lactamase-producing strains and chromosomally mediated resistant strains were 7.2 % and 16.5 %, respectively. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) of ceftriaxone for 7 strains (8.4 %) was 0.125 mu g/ml. One strain was resistant to cefixime (MIC 0.5 mu g/ml). The MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin, and tosufloxacin, showed a bimodal distribution. The MIC of sitafloxacin was lower than those of the three fluoroquinolones listed here, and it was found that the antimicrobial activity of sitafloxacin was stronger than that of the fluoroquinolones. The MIC of azithromycin in 2 strains was 2 mu g/ml, but no high-level resistance to macrolides was detected.

• 出版日期2013-8