Androgen Receptor CAG Repeat Polymorphism and Risk of TMPRSS2: ERG-Positive Prostate Cancer

作者：Yoo Sun; Pettersson Andreas; Jordahl Kristina M; Lis Rosina T; Lindstrom Sara; Meisner Allison; Nuttall Elizabeth J; Stack Edward C; Stampfer Meir J; Kraft Peter; Brown Myles; Loda Massimo; Giovannucci Edward L; Kantoff Philip W; Mucci Lorelei A^*

来源：Cancer Epidemiology Biomarkers & Prevention, 2014, 23(10): 2027-2031.

DOI：10.1158/1055-9965.EPI-14-0020

Background: The androgen receptor (AR) is an essential gene in prostate cancer pathogenesis and progression. Genetic variation in AR exists, including a polymorphic CAG repeat sequence that is inversely associated with transcriptional activity. Experimental data suggest that heightened AR activity facilitates formation of TMPRSS2:ERG, a gene fusion present in approximately 50% of tumors of patients with prostate cancer.
Methods: We undertook a nested case-control study to investigate the hypothesis that shorter CAG repeat length would be associated with prostate cancer risk defined by TMPRSS2: ERG status. The study included 291 men with prostate cancer (147 ERG-positive) and 1,221 cancer-free controls. ORs and 95% confidence intervals (CI) were calculated using logistic regression.
Results: Median CAG repeat length (interquartile range) among controls was 22 (20-24). Men with shorter CAG repeats had an increased risk of ERG-positive (OR, 1.07 per 1 repeat decrease; 95% CI, 1.00-1.14), but not ERG-negative prostate cancer (OR, 0.99 per 1 repeat decrease; 95% CI, 0.93-1.05).
Conclusions: These data suggest that shorter CAG repeats are specifically associated with development of TMPRSS2: ERG-positive prostate cancer.
Impact: Our results provide supportive evidence that androgen signaling underlies the development of prostate tumors that harbor TMPRSS2: ERG. Moreover, these results suggest that TMPRSS2: ERG may represent a unique molecular subtype of prostate cancer with an etiology distinct from TMPRSS2: ERG-negative disease.

• 出版日期2014-10