Markers of sulfadoxine-pyrimethamine-resistant Plasmodium falciparum in placenta and circulation of pregnant women

作者:Mockenhaupt Frank P*; Bedu Addo George; Junge Claudia; Hommerich Lena; Eggelte Teunis A; Bienzle Ulrich
来源:Antimicrobial Agents and Chemotherapy, 2007, 51(1): 332-334.
DOI:10.1128/AAC.00856-06

摘要

Placental sequestration of Plasmodium falciparum in pregnancy may impair the usefulness of molecular markers of sulfadoxine-pyrimethamine resistance. In 300 infected, delivering women, the concordance of PCR-restriction fragment length polymorphism-derived parasite resistance alleles in matched samples from placenta and circulation was 83 to 98%. Sulfadoxine-pyrimethamine resistance typing in peripheral blood is reasonably representative of P. falciparum infecting pregnant women.

  • 出版日期2007-1