Diastereoselective synthesis of propargylamines catalyzed by Cu-MCM-41

作者：Cortezano Arellano Omar; Hernandez Gasca Miguel A; Angeles Beltran Deyanira; Negron Silva Guillermo E^*; Santillan Rosa

来源：Tetrahedron Letters, 2018, 59(25): 2403-2406.

DOI：10.1016/j.tetlet.2018.05.010

• Propargylamines
• Diastereoselectivity
• Multicomponent reactions
• Heterogeneous catalysis
• Cu-MCM-41

In this work, a rapid, efficient and protecting group free diastereoselective synthesis of propargylamines through a multicomponent coupling reaction between (S)-prolinol, phenylacetylene and commercially available aldehydes catalyzed by Cu-MCM-41 in heterogeneous phase is reported. The reactions were carried out under solvent free conditions with good yields and moderate reaction times. In all the cases, catalyst was recovered and reused up to five cycles. Recyclability of the catalyst, low catalyst loading, solvent and protecting group free conditions, and the use of inexpensive catalyst are the key features that provide green aspects to this synthetic protocol.

• 出版日期2018-6-20