Antibiotics and the post-genome revolution

作者:Amini Sasan; Tavazoie Saeed*
来源:Current Opinion in Microbiology, 2011, 14(5): 513-518.
DOI:10.1016/j.mib.2011.07.017

摘要

The emergence of pathogenic bacteria resistant to multiple antimicrobial agents is turning into a major crisis in human and veterinary medicine. This necessitates a serious re-evaluation of our approaches toward antibacterial drug discovery and use. Concurrent advances in genomics including whole-genome sequencing, genotyping, and gene expression profiling have the potential to transform our basic understanding of antimicrobial pathways and lead to the discovery of novel targets and therapeutics.

  • 出版日期2011-10