Selective ortho-Bromination of Substituted Benzaldoximes Using Pd-Catalyzed C-H Activation: Application to the Synthesis of Substituted 2-Bromobenzaldehydes

作者：Dubost Emmanuelle; Fossey Christine; Cailly Thomas; Rault Sylvain; Fabis Frederic^*

来源：Journal of Organic Chemistry, 2011, 76(15): 6414-6420.

DOI：10.1021/jo200853j

Substituted 2-bromobenzaldehydes were synthesized from benzaldehydes using a three-step sequence involving a selective palladium-catalyzed ortho-bromination as the key step. O-Methyloxime serves as a directing group in this reaction. A rapid deprotection of substituted 2-bromobenzaldoximes afforded substituted 2-bromobenzaldehydes with good overall yields.

• 出版日期2011-8-5