Hyaluronic acid grafted PLGA copolymer nanoparticles enhance the targeted delivery of Bromelain in Ehrlich's Ascites Carcinoma

作者：Bhatnagar Priyanka; Pant Aditya Bhushan; Shukla Yogeshwer; Panda Amulya; Gupta Kailash Chand^*

来源：European Journal of Pharmaceutics and Biopharmaceutics, 2016, 105: 176-192.

DOI：10.1016/j.ejpb.2016.06.002

• Bromelain
• Hyaluronic acid
• Nanoparticles
• Apoptosis
• Ehrlich's ascites tumors

Rapidly increasing malignant neoplastic disease demands immediate attention. Several dietary compounds have recently emerged as strong anti-cancerous agents. Among, Bromelain (BL), a protease from pineapple plant, was used to enhance its anti-cancerous efficacy using nanotechnology. In lieu of this, hyaluronic acid (HA) grafted PLGA copolymer, having tumor targeting ability, was developed. BL was encapsulated in copolymer to obtain BL-copolymer nanoparticles (NPs) that ranged between 140 to 281 nm in size. NPs exhibited higher cellular uptake and cytotoxicity in cells with high CD44 expression as compared with non-targeted NPs. In vivo results on tumor bearing mice showed that NPs were efficient in suppressing the tumor growth. Hence, the formulation could be used as a self-targeting drug delivery cargo for the remission of cancer.

• 出版日期2016-8