Diet Shapes the Evolution of the Vertebrate Bitter Taste Receptor Gene Repertoire

作者：Li, Diyan; Zhang, Jianzhi^*

来源：Molecular Biology and Evolution, 2014, 31(2): 303-309.

DOI：10.1093/molbev/mst219

• bitter taste receptor
• Tas2r
• herbivore
• carnivore
• omnivore

Vertebrate Tas2r taste receptors bind to bitter compounds, which are typically poisonous, to elicit bitter sensation to prevent the ingestion of toxins. Previous studies noted a marked variation in the number of Tas2r genes among species, but the underlying cause is unclear. To address this question, we compile the Tas2r gene repertoires from 41 mammals, 4 birds, 2 reptiles, 1 amphibian, and 6 fishes. The number of intact Tas2r genes varies from 0 in the bottlenose dolphin to 51 in the Western clawed frog, with numerous expansions and contractions of the gene family throughout vertebrates, especially among tetrapods. The Tas2r gene number in a species correlates with the fraction of plants in its diet. Because plant tissues contain more toxic compounds than animal tissues do, our observation supports the hypothesis that dietary toxins are a major selective force shaping the diversity of the Tas2r repertoire.

• 出版日期2014-2
• 单位四川农业大学