Application of chiral N,N′-dialkyl-1,2-cyclohexanediamine derivatives in asymmetric copper(II)-catalyzed Henry reactions

作者：Zhao Chunhong; Liu, Fei; Gou, Shaohua^*

来源：Tetrahedron: Asymmetry , 2014, 25(3): 278-283.

DOI：10.1016/j.tetasy.2013.12.017

• CATALYST

A series of chiral N,N'-dialkyl-1,2-cyclohexanediamine derivatives were designed, synthesized, and applied as ligands in asymmetric copper(II)-catalyzed Henry reactions. The catalysts based on such ligands and copper(II) acetate were found to promote asymmetric Henry reactions between aromatic/aliphatic aldehydes and nitromethane efficiently, and could provide the corresponding beta-nitroalcohols in very good yields and with enantioselectivities of up to 93.6%.

• 出版日期2014-2-15
• 单位东南大学