Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data

作者：Randerson Moor Juliette A; Taylor John C; Elliott Faye; Chang Yu Mei; Beswick Samantha; Kukalizch Kairen; Affleck Paul; Leake Susan; Haynes Sue; Karpavicius Birute; Marsden Jerry; Gerry Edwina; Bale Linda; Bertram Chandra; Field Helen; Barth Julian H; Silva Isabel dos Santos; Swerdlow Anthony; Kanetsky Peter A; Barrett Jennifer H; Bishop D Timothy; Bishop Julia A Newton^*

来源：European Journal of Cancer, 2009, 45(18): 3271-3281.

DOI：10.1016/j.ejca.2009.06.011

• Vitamin D
• Breslow thickness
• Heredity
• Body mass index

We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D(3) levels in order to investigate the role of vitamin D in melanoma susceptibility. There was no significant evidence of an association between any VDR SNP and risk in 1028 population-ascertained cases and 402 controls from Leeds, UK. In a second Leeds case-control study (299 cases and S60 controls) the FokI T allele was associated with increased melanoma risk (odds ratio (OR) 1.42, 95% confidence interval (CI) 1.06-1.91, p = 0.02). In a meta-analysis in conjunction with published data from other smaller data sets (total 3769 cases and 3636 controls), the FokI T allele was associated with increased melanoma risk (OR 1.19, 95% CI 1.05-1.35), and the BsmI A allele was associated with a reduced risk (OR 0.81, 95% Cl 0.72-0.92), in each instance under a parsimonious dominant model. In the first Leeds case-control comparison cases were more likely to have a higher body mass index (BMI) than controls (p = 0.007 for linear trend). There was no evidence of a case-control difference in serum 25-hydroxyvitamin D(3) levels. In 1043 incident cases from the first Leeds case-control study, a single estimation of serum 25-hydroxyvitamin D(3) level taken at recruitment was inversely correlated with Breslow thickness (p = 0.03 for linear trend). These data provide evidence to support the view that vitamin D and VDR may have a small but potentially important role in melanoma susceptibility, and putatively a greater role in disease progression.

• 出版日期2009-12