Modulation of antigen-specific T-cells as immune therapy for chronic infectious diseases and cancer

作者：Li Suling; Symonds Alistair L J; Miao Tizong; Sanderson Ian; Wang Ping^*

来源：Frontiers in Immunology, 2014, 5: 293.

DOI：10.3389/fimmu.2014.00293

• tolerance induction
• antigen-specificT cells
• bystander T-cells
• nanoAPC
• reverse tolerance

T-cell responses are induced by antigen presenting cells (ARC) and signals from the microenvironment. Antigen persistence and inflammatory microenvironments in chronic infections and cancer can induce a tolerant state in T-cells resulting in hyporesponsiveness, loss of effector function, and weak biochemical signaling patterns in response to antigen stimulation. Although the mechanisms of T-cell tolerance induced in chronic infection and cancer may differ from those involved in tolerance to self-antigen, the impaired proliferation and production of IL-2 in response to antigen stimulation are hallmarks of all tolerant T cells. In this review, we will summarize the evidence that the immune responses change from non-self to %26quot;self%26quot;-like in chronic infection and cancer, and will provide an overview of strategies for re-balancing the immune response of antigen-specific T cells in chronic infection and cancer without affecting the homeostasis of the immune system.

• 出版日期2014-6-17