Association between interleukin 15 receptor, alpha (IL15RA) polymorphism and Korean patients with ossification of the posterior longitudinal ligament

作者：Kim Dong Hwan; Jeong Yong Seol; Chon Jinmann; Yoo Seung Don; Kim Hee Sang; Kang Sung Wook; Chung Joo Ho; Kim Ki Tack; Yun Dong Hwan^*

来源：Cytokine, 2011, 55(3): 343-346.

DOI：10.1016/j.cyto.2011.05.016

• Ossification of the posterior longitudinal ligament
• Interleukin 15 receptor
• Alpha
• Single nucleotide polymorphism
• Association study

Objectives: Recently, a number of evidences have been reported concerning the genetic factor involved in the development of ossification of the posterior longitudinal ligament (OPLL). The purpose of this study was to investigate single nucleotide polymorphisms (SNPs) of the interleukin 15 receptor, alpha (IL15RA) gene as a risk factor in Korean patients with OPLL.
Design: To investigate the genetic association, two coding SNPs (rs2296139, Thr73Thr; rs2228059, Asn182Thr) in IL15RA were genotyped in 166 OPLL patients and 230 control subjects. SNPStats, SNPAnalyzer, and Helixtree programs were used for association analysis.
Results: In the present study, we found the association between a missense SNP (rs2228059) and the risk of OPLL in codominant (p = 0.0028, OR = 1.58, 95% CI = 1.17-2.14), dominant (p = 0.0071, OR = 1.82, 95% CI = 1.17-2.82), and recessive models (p = 0.036, OR = 1.79, 95% CI = 1.04-3.09). The frequency of rs2228059 allele was significantly associated with the susceptibility of OPLL (p = 0.0043, OR = 1.52, 95% CI = 1.14-2.02). After Bonferroni correction, the missense SNP (rs2228059, Asn182Thr) still had significant correlations (p = 0.0056 in codominant model; p = 0.0142 in dominant model; p = 0.0086 in allele analysis). Haplotype variation in IL15RA was associated with OPLL (global haplotype test, p = 0.025).
Conclusions: These results suggest that IL15RA polymorphism may be associated with the susceptibility of OPLL in Korean population.

• 出版日期2011-9