A Descriptive Case Series of Patients with End-Stage Liver Disease Hospitalized with Variceal Bleeding Who Received Pharmacologic Venous Thromboembolism Prophylaxis

作者：Schleyer Anneliese M^*; Smith Mark W; Jarman Kenneth M; Crane Paul K; Schreuder Astrid B; Goss J Richard

来源：Journal of Hospital Medicine, 2011, 6(3): 151-155.

DOI：10.1002/jhm.777

• liver disease
• thromboembolism prophylaxis
• variceal bleeding

BACKGROUND: It is unknown whether venous thromboembolism prophylaxis (VTEP) should be utilized in hospitalized patients with end-stage liver disease ( ESLD), particularly in those admitted with variceal bleeding.
OBJECTIVE: We sought to describe a cohort of patients who received pharmacologic VTEP, specifically identifying the occurrence of rebleeding.
DESIGN: Descriptive case series.
SETTING/PATIENTS: All adult patients with ESLD admitted to an urban county teaching hospital over three years with variceal bleeding who received pharmacologic VTEP during hospitalization.
RESULTS: A total of 22 patients with ESLD and variceal bleeding received pharmacologic VTEP. Only 1 patient rebled after initiation of VTEP; 2 patients were diagnosed with lower extremity deep venous thrombosis while on VTEP including the 1 patient who rebled.
CONCLUSIONS: VTEP was associated with an unexpectedly low incidence of recurrent bleeding in patients with ESLD and variceal bleeding. Further study may be warranted. Journal of Hospital Medicine 2011;6:151-155.

• 出版日期2011-3