Glyoxalase I Glu111Ala Polymorphism in Patients with Breast Cancer

作者：Germanova Alexandra; Germanova Anna; Tesarova Petra; Jachymova Marie; Zvara Karel; Zima Tomas; Kalousova Marta^*

来源：Cancer Investigation, 2009, 27(6): 655-660.

DOI：10.1080/07357900802350822

• Glyoxalase I
• Advanced glycation end products
• AGEs
• Breast cancer
• Soluble receptor for advanced glycation end products
• sRAGE

Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluble RAGE or by reducing AGE-precursors via glyoxalase I. Glu111Ala polymorphism of glyoxalase I gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls. Higher frequency of the mutated C allele was found in patients with negative estrogen receptors and in patients in clinical stage III compared to controls (P 0.05). The presence of the C allele could represent a negative prognostic factor; however, further studies are needed to confirm this hypothesis.

• 出版日期2009