Adjusted Confidence Intervals for a Bounded Parameter

作者：Wu Hao^*; Neale Michael C

来源：Behavior Genetics, 2012, 42(6): 886-898.

DOI：10.1007/s10519-012-9560-z

• Confidence interval
• Variance component
• Likelihood ratio test
• Wald test
• ACDE models

It is well known that the regular likelihood ratio test of a bounded parameter is not valid if the boundary value is being tested. This is the case for testing the null value of a scalar variance component. Although an adjusted test of variance component has been suggested to account for the effect of its lower bound of zero, no adjustment of its interval estimate has ever been proposed. If left unadjusted, the confidence interval of the variance may still contain zero when the adjusted test rejects the null hypothesis of a zero variance, leading to conflicting conclusions. In this research, we propose two ways to adjust the confidence interval of a parameter subject to a lower bound, one based on the Wald test and the other on the likelihood ratio test. Both are compatible to the adjusted test and parametrization-invariant. A simulation study and two examples are given in the framework of ACDE models in twin studies.

• 出版日期2012-11