A 3-Step Therapeutic Strategy for Severe Alveolar Proteinosis

作者：Noirez Leslie; Koutsokera Angela; Pantet Olivier; Duss Francois Regis; Eggimann Philippe; Tozzi Piergiorgio; Gonzalez Michel; Coronado Marcos; Nicod Laurent P; Lovis Alban^*

来源：Annals of Thoracic Surgery, 2015, 99(4): 1456-1458.

DOI：10.1016/j.athoracsur.2014.12.080

Pulmonary alveolar proteinosis (PAP) is characterized by accumulation of lipoproteinaceous material in the terminal airways. Whole lung lavage (WLL) remains the gold standard treatment but may be particularly challenging in cases of severe hypoxemia. We present a 3-step strategy that was used in a patient with PAP-associated refractory hypoxemia and that combined venovenous extracorporeal membrane oxygenation (vvECMO), double-lumen orotracheal intubation, and bilateral multisegmental sequential lavage (MSL). The procedure was well tolerated and permitted weaning from the ventilator.

• 出版日期2015-3-27