Mechanisms of GABA(A) receptor assembly and trafficking - Implications for the modulation of inhibitory neurotransmission

作者：Kittler JT; McAinsh K; Moss SJ^*

来源：Molecular Neurobiology, 2002, 26(2-3): 251-268.

DOI：10.1385/MN:26:2-3:251

• gephyrin
• PLIC
• GABARAP
• assembly
• endoplasmic reticulum
• ER
• targeting
• inhibitory
• synapse
• GABA
• ion channel
• endocytosis
• receptor
• dynamin
• NSF
• AP2
• clathrin

Fast synaptic inhibition in the brain is largely mediated by ionotropic GABA receptors, which can be subdivided into GABA(A) and GABA(C) receptors based on pharmacological and molecular criteria. GABA(A) receptors are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. In addition, modulating the efficacy of GABAergic neurotransmission may play a key role in neuronal plasticity. Recent studies have begun to reveal that the accumulation of ionotropic GABA(A) receptors at synapses is a highly regulated process that is facilitated by receptor-associated proteins and other cell-signaling molecules. This review focuses on recent experimental evidence detailing the mechanisms that control the assembly and transport of functional ionotropic GABA(A) receptors to cell surface sites, in addition to their stability at synaptic sites. These regulatory processes will be discussed within the context of the dynamic modulation of synaptic inhibition in the central nervous system (CNS).

• 出版日期2002-12