Determination of alpha-Lipoic acid on a Pyrolytic Graphite Electrode Modified with Cobalt Phthalocyanine

作者：Ferreira Ana Paula M; dos Santos Pereira Laise N; da Silva Ir****do Santos; Tanaka Sonia M C N; Tanaka Auro A; Angnes Lucio^*

来源：Electroanalysis, 2014, 26(10): 2138-2144.

DOI：10.1002/elan.201400421

• alpha-Lipoic acid
• Cobalt phthalocyanine
• Electrochemical sensor
• Modified electrode

In this work voltammetric techniques were explored for quantification of a-Lipoic acid (ALA) using a pyrolytic graphite electrode modified with cobalt phthalocyanine. Cyclic voltammograms recorded in phosphate buffer solution containing 1 x 10(-3) mol L-1 of ALA presented an oxidation peak located at +0.8 V vs. SCE. The modification of the electrode produced a 100 mV shift of the onset oxidation potential to less positive value and a substantial increase in the ALA oxidation current. Among the voltammetric techniques explored, differential pulse voltammetry showed the best performance for quantifications of the analyte in low concentrations. Limits of detection and quantification of ALA obtained corresponds to 3.4 x 10(-9) mol L-1 and 1.2 x 10(-8) mol L-1, respectively.

• 出版日期2014-10