A quantitative trait locus for faecal worm egg and blood eosinophil counts on chromosome 23 in Australian goats

作者：Bolormaa S^*; van der Werf J H J; Walkden Brown S W; Marshall K; Ruvinsky A

来源：Journal of Animal Breeding and Genetics, 2010, 127(3): 207-214.

DOI：10.1111/j.1439-0388.2009.00824.x

• eosinophil counts
• faecal worm egg counts
• linkage map
• quantitative trait loci

P>Three microsatellite markers on goat chromosome 23 adjacent to the MHC were used to test for quantitative trait loci (QTL) affecting faecal worm egg count (WEC) and leukocyte traits in ten Australian Angora and twelve Australian Cashmere half-sib families (n = 16-57 per family). Data were collected from 280 Angora and 347 Cashmere kids over a 3- and 4-year period. A putative QTL affecting trichostrongyle WEC was found in two small families at the 5% chromosome-wise threshold level. The biggest QTL effect for WEC of 1.65 standard deviations (sigma(p)) was found within the region of OarCP73-BM1258. A significant QTL affecting blood eosinophil counts at the 1% chromosome-wise threshold level was detected at marker BM1258 (at 26 cM) in two Angora and Cashmere families. The magnitude of the putative QTL was 0.69 and 0.85 sigma(p) in Angora and Cashmere families, respectively. Due to the comparatively low power of the study these findings should be viewed as indicative rather than definitive.

• 出版日期2010-6