Armadillo-repeat protein functions: questions for little creatures

作者：Tewari Rita; Bailes Elizabeth; Bunting Karen A; Coates Juliet C^*

来源：Trends in Cell Biology, 2010, 20(8): 470-481.

DOI：10.1016/j.tcb.2010.05.003

Armadillo (ARK-repeat proteins form a large family with diverse and fundamental functions in many eukaryotes. ARM-repeat proteins have largely been characterised in multicellular organisms and much is known about how a subset of these proteins function. The structure of ARM-repeats allows proteins containing them to be functionally very versatile. Are the ARM-repeat proteins in 'little creatures' as multifunctional as their better-studied relatives? The time is now right to start analysing ARM-repeat proteins in these new systems to better understand their cell biology. Here, we review recent advances in understanding the many cellular roles of both well-known and novel ARM-repeat proteins.

• 出版日期2010-8