Associations of plasma IL-8 levels with Helicobacter pylori seropositivity, gastric atrophy, and IL-8 T-251A genotypes

作者：Naito M^*; Eguchi H; Goto Y; Kondo T; Nishio K; Ishida Y; Kawai S; Okada R; Hishida A; Wakai K; Hamajima N

来源：Epidemiology and Infection, 2010, 138(4): 512-518.

DOI：10.1017/S0950268809990677

• Helicobacter pylori
• interleukin-8
• plasma
• polymorphism

There are few data on circulatory pro-inflammatory cytokine levels and cytokine gene polymorphisms in H. priori-positive patients. A cross-sectional study was conducted to examine the effects of H. pylori infection, gastric atrophy, and the IL-8 T-.251A polymorphism on plasma IL-8 levels in 98 Japanese adults. Seventy-one subjects were positive for H. pylori infection. The geometric mean of plasma IL-8 concentration was significantly higher in subjects with H. pylori infection than in those without (P=0.001). The development of atrophy was negatively associated with IL-8 levels in the H. pylori-positive subjects, although not significantly. Plasma IL-8 levels in the T/T genotype were associated with H. pylori infection and atrophy status (P=0.016). Our findings suggested that circulating IL-8 levels were associated with H. pylori infection. The effect of H. pylori infection on plasma IL-8 levels was not clearly modified by the IL-8 T-251A polymorphism.

• 出版日期2010-4