A Modular Synthetic Route to Dimeric Calixarenes: A New Family of DNA Major Groove Binders

作者：Blecking C J^*; Hu W; Zadmard R; Dasgupta A; Schrader T

来源：Synthesis, 2011, (8): 1193-1204.

DOI：10.1055/s-0030-1259980

• DNA
• major groove
• sequence selectivity
• binding affinity
• calixarenes
• oligopyrroles

We describe here a general strategy for the synthesis of dimeric anilinium/guanidinium calix[4]arenes with aliphatic and heteroaromatic bridges. These compounds display a remarkably high affinity towards double-stranded (ds) DNA and act by a rare mechanism, i.e., insertion into the wide major groove of the nucleic acids.

• 出版日期2011-4