A transdermal review on permeation of drug formulations, modifier compounds and delivery methods

作者：Rai V; Ghosh I; Bose S; Silva S M C; Chandra P; Michniak Kohn B^*

来源：Journal of Drug Delivery Science and Technology, 2010, 20(2): 75-87.

• Percutaneous drug delivery
• Formulation effect
• Pig skin
• Rat skin
• Human skin equivalents
• Permeation modifiers
• Flux
• Enhancers
• Retardants
• Biochemistry of skin
• In vivo/in vitro correlation (IVIVC)
• Organization for Economic Co-operation and Development(OECD)

This article systematically reviews the status of in vitro and in vivo percutaneous permeation of selected compounds reported in the literature and attempts to relate these permeation data to formulations and biochemical changes occurring in human skin, animal skins and skin equivalents. A substantial portion of the article is dedicated in reviewing the status of commercially available drugs and their delivery methods. Information on permeation modifier compounds and in vivo/in vitro (IVIVC) correlations is also provided in order to obtain a complete picture of the research status in the dermatopharmaceutical field.

• 出版日期2010-4