A report on single exon genes (SEG) in eukaryotes

作者：Sakharkar MK; Chow VTK; Chaturvedi I; Mathura VS; Shapshak P; Kangueane P^*

来源：Frontiers in Bioscience, 2004, 9: 3762-3767.

• SEG
• eukaryotic genomes
• protein length
• distribution
• evolution

Single exon genes (SEG) are archetypical of prokaryotes. Hence, their presence in intron-rich, multicellular eukaryotic genomes is perplexing. Consequently, a study on SEG origin and evolution is important. Towards this goal, we took the first initiative of identifying and counting SEG in nine completely sequenced eukaryotic organisms - four of which are unicellular ( E. cuniculi, S. cerevisiae, S. pombe, P. falciparum) and five of which are multi-cellular ( C. elegans, A. thaliana, D. melanogaster, M. musculus, H. sapiens). This exercise enabled us to compare their proportion in unicellular and multi-cellular genomes. The comparison suggests that the SEG fraction decreases with gene count (r = - 0.80) and increases with gene density ( r = 0.88) in these genomes. We also examined the distribution patterns of their protein lengths in different genomes.

• 出版日期2004-9-1
• 单位南阳理工学院