A Reported "New Synthesis of Lysergic Acid" Yields Only The Derailment Product: Methyl 5-Methoxy-4,5-dihydroindolo[4,3-f,g]quinoline-9-carboxylate

作者：Bekkam Markondaiah; Mo Huaping; Nichols David E^*

来源：Organic Letters, 2012, 14(1): 296-298.

DOI：10.1021/ol203048q

The treatment of ethyl 6-formy1-5-(1H-Indol-411)pyridine-3-carboxylate (2) with NaOMe or NaOH in methanol solution at room temperature under the reported reaction conditions afforded solely product 4 in 80% yield, rather than anticipated product 3.

• 出版日期2012-1-6